How does knowing a transition point affect how i design my mesh? I am running an airfoil simulation for low reynolds number and cannot seem to match the drag coefficient. Please help

Cheerios Rif

Are you sure that the flow is going to transition? If the flow remains laminar or can be assumed fully turbulent then the location of the transition point is not important. If the flow is supposed to transition as part of your simulation then you need to look at the transition model in your code for any specific gridding constraints. A simple point model, where the flow is assumed to transition instantly, doesn't require any special gridding beyond the standard caveats of being able to resolve the normal gradients in the wall region. Have you traced your drag issue to a problem with transition, or are you simply guessing?