I am PhD student. Is this possible to make the code to consider all the effects of solar radiation, heat transfer and natural ventilation for a room with opening, shading and wall. I do not know the difficulty and how well it will be. Or is there any available software could solve the problem? Please give some advice. Thank you!

It is possible, of course. You may take all these effects as boundary conditions with an existing CFD code.

Alternatively, this can be done starting with the outdoor conditions. In this case, you need a database of the outdoor climate parameters....

How difficult is it? Well, this can be a work for your PhD disertation.