CFD Online Logo CFD Online URL
www.cfd-online.com
[Sponsors]
Home > Forums > FLUENT

Modelling Drug eluting stents

Register Blogs Members List Search Today's Posts Mark Forums Read

Reply
 
LinkBack Thread Tools Display Modes
Old   July 4, 2012, 02:57
Default Modelling Drug eluting stents
  #1
Member
 
Dr. Moloy Kumar Banerjee
Join Date: Jun 2011
Posts: 71
Rep Power: 6
moloykb is on a distinguished road
Atherosclerosis is the most common arterial disease and is responsible for heart attacks and strokes. The insertion of a stent to the affected area can increase the lumen and act as a scaffold to hold the walls apart. The stent itself is essentially a small metal mesh tube and is inserted into the affected area on a balloon catheter, which is expanded and then removed, leaving the stent in place. However, this can provoke an inflammatory response which can lead to restenosis—the thickening over of the vessel wall. Drug-eluting stents are stents that are coated with a drug, often embedded in a polymer. The drug is released slowly, interrupting the smooth muscle cell cycle and thus their proliferation. This, in turn, can significantly reduce restenosis.
Now, my problem is that how to formulate the same in Fluent. Anybody working on this field please share the experience.
moloykb is offline   Reply With Quote

Old   July 5, 2012, 19:10
Default
  #2
Member
 
Casey
Join Date: Jun 2009
Posts: 96
Rep Power: 8
meangreen is on a distinguished road
I would model the artery(ies) in gambit and create a zone in the region you would like to model the stent.

In fluent use eulerian modeling and make the stent zone a packed bed. Use a UDF to define the pressure drop through the stent over time (using Darcy's law or something). You will need to make assumptions on the amount of drug that dissolves from the stent, which will affect the pressure drop.
meangreen is offline   Reply With Quote

Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are On
Pingbacks are On
Refbacks are On


Similar Threads
Thread Thread Starter Forum Replies Last Post
error message cuteapathy CFX 14 March 20, 2012 07:45
Advice on multi-phase flow modelling Martin Main CFD Forum 3 October 14, 2008 05:16
Unsteady modelling technique? Carlos FLUENT 0 September 26, 2008 11:37
how to ensure that your modelling is correct rvndr Main CFD Forum 7 March 1, 2004 13:21
Computational Modelling of Vortex Separators May Lim Main CFD Forum 6 November 13, 1998 13:36


All times are GMT -4. The time now is 03:35.