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Job Record #17370
TitlePhD Studentship - Aerosols in Medicine
CategoryPhD Studentship
EmployerVirginia Commonwealth University
LocationUnited States, Virginia, Richmond
InternationalYes, international applications are welcome
Closure DateFriday, April 15, 2022
Description:
Title:  PhD Studentship – Aerosols in Medicine: CFD Simulations of Complete-
Airway Models and DPI Design

The Aerosols in Medicine (AIM) Lab in the VCU College of Engineering 
(directed by Dr. Longest) seeks to address significant current challenges in 
the field of medical aerosols in order to improve the treatment of 
respiratory and systemic diseases and conditions including chronic lung 
infections, asthma, chronic obstructive pulmonary disease (COPD), cystic 
fibrosis, surfactant insufficiency and acute respiratory distress syndrome.

To address challenges in the field of aerosolized medicine, the AIM lab 
specializes in a thorough understanding of transport phenomena including 
fluid mechanics, heat and mass transfer, turbulence, thermodynamics, 
pharmacokinetics and multiphase flows, together with aerosol science, lung 
biology and lung physiology.  Specific skills developed by lab members often 
fall into the areas of:

•  Computational fluid dynamics (CFD)
•  Inhaler and aerosol generation/delivery device development
•  Development and use of characteristic and complete airway models
•  Particle engineering

These skills are applied to various aspects of the medical aerosol delivery 
process from particle formation during spray drying and aerosol generation 
within an inhaler through particle deposition in the distal airways and 
post-deposition transport including drug dissolution, absorption and 
clearance.

Project Description: Areas of focus will include CFD simulations of 
pharmaceutical aerosol transport in complete-airway models and 
implementation of CFD for the optimization of dry powder inhalers (DPIs).  
Our group has previously developed methods for complete-airway simulations 
of pharmaceutical aerosols.  The successful applicant will work to extend 
these methods and apply them in the areas of targeted therapeutic aerosol 
delivery (NIH) and numerical assessment of generic inhaler product 
performance (US FDA).  In the area of dry powder inhaler (DPI) design, our 
group has previously developed a range of DPIs based on air-jet technology.  
The successful applicant will implement CFD modeling to understand 
pharmaceutical aerosol formation within air-jet DPIs and optimize their 
performance for a range of applications, including aerosol administration to 
infants and children (NIH and Bill and Melinda Gates Foundation).

Work in the AIM lab is currently funded through the Bill and Melinda Gates 
Foundation, National Institutes of Health (NIH), and US Food and Drug 
Administration (FDA).

More Information about the AIM Lab and group publications can be found at:
https://sites.google.com/vcu.edu/longest-lab/home
https://scholar.google.com/citations?user=w8MxYJYAAAAJ&hl=en

Position Opening: Spring or Fall 2022

Applications Instructions:  Interested candidates should email a cover 
letter of interest, resume, transcripts (unofficial), and list of three 
references to Prof. Longest (pwlongest@vcu.edu). Applications will be 
reviewed upon receipt and accepted until the position is filled.
 
Additional Information

The Mechanical and Nuclear Engineering Department at VCU offers a highly 
interdisciplinary research experience, which is essential for the study of 
pharmaceutical aerosols.  Areas of expertise include transport modeling, 
computational fluid dynamics, life science engineering, and pharmaceutics.  
This project is being performed in collaboration with the VCU Department of 
Pharmaceutics, which is located on the VCU Medical Campus.  The VCU 
Department of Pharmaceutics is widely recognized for its Aerosol Research 
Group, which specializes in the area of respiratory drug delivery, and is 
the developer of the Respiratory Drug Delivery (RDD) Conference series 
(http://www.rddonline.com/), which currently hosts ~700 attendees to 
national and international conference sites each year.

Contact Information:
Please mention the CFD Jobs Database, record #17370 when responding to this ad.
NameWorth Longest
Emailpwlongest@vcu.edu
Email ApplicationYes
Phone8048277023
URLhttps://sites.google.com/vcu.edu/longest-lab/home
Address401 West Main Street
PO Box 843015
Record Data:
Last Modified03:24:03, Friday, September 24, 2021

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