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shear stress in cell-laden hydrogel (3D-plotting) |
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April 17, 2018, 15:26 |
shear stress in cell-laden hydrogel (3D-plotting)
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#1 |
New Member
Jasmina
Join Date: Apr 2018
Location: Germany
Posts: 11
Rep Power: 8 |
Hello!
I am about to start my diploma thesis in the field of simulation of 3D-plotting (bioprinting) process. In that process, a hydrogel flows through a nozzel (0.5 mm diam.) an should form a small construct when hardening. This hydrogel (Alginate) contains cells. There is an interest in obtaining the shear stress affecting the cells. Therefore a numerical calculation (simulation) should determine and illustrate the pressure-induced shear stress prevailing in the nozzel. Unfortunatly I am still a beginner in building simulations, i just did a laminar fluid flow simulation (non newtonian fluid) with ANSYS CFX. So the first, biggest questions are: When is it necessary to include the cells as particals in a slurry? Or is it sufficient to model the hydrogel as a non newtonian fluid with the according (rheological) fluid data, and NO particals included? I think you could assume shear stress acting on the Hydrogel = shear stress acting on the cells. Is this a concentration-depending decision? Or a cell size-depending one? When considering a slurry, which fluid models can be put into question? Is openFoam a possible software to handle those? Is this a problem of DEM (discrete element method) - and not FEM / FVM anymore? Many questions, Im sorry. It would be a giant help finding some answers or if you could recommend some sources for my "basics"-research. (Gladly in german ) Many Thanks! |
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March 19, 2019, 06:45 |
Shear stress in collagen matrix
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#2 |
New Member
Sri Nivas Chandrasekaran
Join Date: Feb 2019
Posts: 6
Rep Power: 7 |
Hi Jasmina,
Were you able to find an answer to the question? I am trying to model cells in a collagen matrix (laminar flow) using openFoam. Is it enough if I consider it as a non-Newtonian fluid? Did you model the cells too? Your reply would be helpful. Thanks! |
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dem, particle concentration, polymer, slurry flow, viscocity |
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