CFD Online Logo CFD Online URL
www.cfd-online.com
[Sponsors]
Home > Forums > General Forums > Main CFD Forum

shear stress in cell-laden hydrogel (3D-plotting)

Register Blogs Members List Search Today's Posts Mark Forums Read

Like Tree2Likes
  • 1 Post By Jasmina92
  • 1 Post By srinc

Reply
 
LinkBack Thread Tools Search this Thread Display Modes
Old   April 17, 2018, 15:26
Default shear stress in cell-laden hydrogel (3D-plotting)
  #1
New Member
 
Jasmina
Join Date: Apr 2018
Location: Germany
Posts: 11
Rep Power: 6
Jasmina92 is on a distinguished road
Hello!
I am about to start my diploma thesis in the field of simulation of 3D-plotting (bioprinting) process.
In that process, a hydrogel flows through a nozzel (0.5 mm diam.) an should form a small construct when hardening.

This hydrogel (Alginate) contains cells. There is an interest in obtaining the shear stress affecting the cells.
Therefore a numerical calculation (simulation) should determine and illustrate the pressure-induced shear stress prevailing in the nozzel.
Unfortunatly I am still a beginner in building simulations, i just did a laminar fluid flow simulation (non newtonian fluid) with ANSYS CFX.

So the first, biggest questions are:
When is it necessary to include the cells as particals in a slurry?
Or is it sufficient to model the hydrogel as a non newtonian fluid with the according (rheological) fluid data, and NO particals included? I think you could assume shear stress acting on the Hydrogel = shear stress acting on the cells.
Is this a concentration-depending decision? Or a cell size-depending one?
When considering a slurry, which fluid models can be put into question? Is openFoam a possible software to handle those? Is this a problem of DEM (discrete element method) - and not FEM / FVM anymore?

Many questions, Im sorry. It would be a giant help finding some answers or if you could recommend some sources for my "basics"-research. (Gladly in german )
Many Thanks!
sourav90 likes this.
Jasmina92 is offline   Reply With Quote

Old   March 19, 2019, 06:45
Default Shear stress in collagen matrix
  #2
New Member
 
Sri Nivas Chandrasekaran
Join Date: Feb 2019
Posts: 6
Rep Power: 5
srinc is on a distinguished road
Hi Jasmina,

Were you able to find an answer to the question? I am trying to model cells in a collagen matrix (laminar flow) using openFoam. Is it enough if I consider it as a non-Newtonian fluid? Did you model the cells too? Your reply would be helpful. Thanks!
sourav90 likes this.
srinc is offline   Reply With Quote

Reply

Tags
dem, particle concentration, polymer, slurry flow, viscocity

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Trackbacks are Off
Pingbacks are On
Refbacks are On


Similar Threads
Thread Thread Starter Forum Replies Last Post
Shear Stress Calculation in the flow. auburnuser FLOW-3D 11 May 12, 2018 14:49
Plotting Shear Stress michael.collins STAR-CCM+ 1 January 21, 2016 12:39
How to get Axial-Wall Shear Stress killsecond FLUENT 0 June 24, 2015 04:14
Journal file error magicalmarshmallow FLUENT 3 April 4, 2014 13:25
Cells with t below lower limit Purushothama Siemens 2 May 31, 2010 22:58


All times are GMT -4. The time now is 11:47.